多篇双盲安慰剂对照试验的报告证实口服无环鸟苷预防频繁复发性生殖器疱疹的疗效。连续应用长达5年的每日预防性治疗是安全有效的。对于免疫功能正常的患者,无环鸟苷的治疗结果与体外抗药性无关联。曾有报道在HIV感染的免疫受损宿主,由于对无环鸟苷耐药导致治疗失败。无环鸟苷在妊娠期的安全性尚未被证实。总之,口服无环鸟苷在长期预防频繁复发性生殖器疱疹中是唯一有效且安全的抗病毒药物。 Multiple double-blind placebo-controlled trials confirm the efficacy of oral acyclovir in the prevention of recurrent genital herpes. It is safe and effective to use continuous daily preventive treatment up to 5 years. For patients with normal immune function, the results of acyclovir treatment are not associated with in vitro resistance. It has been reported that immunocompromised hosts in HIV infection fail treatment due to resistance to acyclovir. Acyclovir safety in pregnancy has not been confirmed. In conclusion, oral acyclovir is the only potent and safe antiviral drug for long-term prevention of frequent recurrent genital herpes.