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目的：观察２型糖尿病患者血ｔＰＡ和ＰＡＩ－１水平变化及其相关因素。方法：同时测定６８例２型糖尿病患者血ｔＰＡ、ＰＡＩ－１、胰岛素、甘油三脂、胆固醇、ＬＤＬ—Ｃ、ＨＤＬ－Ｃ和尿白蛋白。结果；①与正常对照组（Ｃ组）比较，糖尿病患者血ｔＰＡ活性明显降低，ＰＡＩ－１活性明显升高，Ｐ＜０．０５；正常白蛋白尿患者ｔＰＡ活性无明显变化，但ＰＡＩ－１活性升高， Ｐ＜ ０． ０５；微量白蛋白尿患者 ｔＰＡ活性明显降低， ＰＡＩ－ １活性明显升高；大量白蛋白尿患者 ｔＰＡ活性进一步降低，ＰＡＩ－１活性进一步升高；②与Ｃ组比较，糖尿病患者，尤其伴微量和大量白蛋白尿，空腹胰岛素水平和血脂明显升高。结论：２型糖尿病患者，尤其伴白蛋白尿患者，常存在明显的纤溶障碍。
Objective: To observe the changes of blood levels of tPA and PAI-1 in patients with type 2 diabetes mellitus and its related factors. Methods: The levels of tPA, PAI-1, insulin, triglyceride, cholesterol, LDL-C, HDL-C and urinary albumin in 68 type 2 diabetic patients were measured simultaneously. Results ①Compared with the normal control group (C), tPA activity in diabetic patients was significantly decreased and PAI-1 activity was significantly increased, P <0.05; tPA activity in normal albuminuria patients did not change significantly, but PAI-1 Activity increased, P <0. 05; microalbuminuria in patients with tPA activity was significantly lower, PAI-1 activity was significantly increased; a large number of patients with albuminuria tPA activity was further reduced, PAI-1 activity further increased; ② compared with the C group, diabetic patients, especially with trace And a lot of albuminuria, fasting insulin levels and blood lipids were significantly higher. Conclusion: Patients with type 2 diabetes, especially those with albuminuria, often have obvious fibrinolytic disorders.