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用乌拉坦给小白鼠饮用或皮下注射均可诱发肺腺瘤,少数动物还发生胸腺恶性淋巴瘤。实验开始后22天,动物肺内即可有肺泡细胞瘤性增生;63天时有部分动物发生肺腺瘤(发生率11.1~36.3%),164天时所有实验组动物都发生肺肿瘤。不同途径给药对肿瘤发生无明显影响。由于这种化合物结构简单、致癌性强、诱发肿瘤潜伏期短,已被广泛用于肿瘤病因学、发病学及实验治疗等方面的研究。本文还对其致癌作用机理及肿瘤性质和此类物质对人的潜在危害性进行了讨论。
With urethane to mice to drink or subcutaneous injection can induce lung adenoma, a few animals also occur thymus lymphoma. Twenty-two days after the start of the experiment, alveolar cell tumor was proliferated in the lungs of the animals; some of the animals developed pulmonary adenomas (incidence of 11.1-36.3%) at 63 days. All animals in the experimental group developed lung tumors at 164 days. Different routes of administration had no significant effect on tumorigenesis. Because of its simple structure, strong carcinogenicity and short incubation period, it has been widely used in tumor etiology, pathogenesis and experimental treatment. This article also discussed its carcinogenic mechanism and the nature of the tumor and the potential hazard of such substances to humans.