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目的观察江西省新建县湖区南矶乡血吸虫病重度流行区用蒿甲醚预防日本血吸虫感染的效果。方法2004年5月至11月,以南矶乡的南山岛为试点,居民以半农半渔为业,选择6～65岁居民随机分为蒿甲醚一组、蒿甲醚二组和对照组。在服蒿甲醚前30d,经粪便血吸虫卵检查后,全民服单剂吡喹酮40mg/kg治疗。蒿甲醚一组每半个月服一次蒿甲醚6mg/kg,共13次;蒿甲醚二组每个月服一次蒿甲醚6mg/kg,共7次;对照组服相同剂量的安慰剂。全程用双盲法进行粪检、服药和观察。末次服药后40～60d作粪检复查。结果蒿甲醚一组413例的粪检虫卵阳性率为3.4%,明显低于对照组587例粪检的虫卵阳性率13.5%,保护率为74.8%;蒿甲醚二组402例粪检的感染率为10.5%,与对照组的差别不显著。结论在血吸虫病传播季节,每半个月服1次蒿甲醚6mg/kg,对湖区重度流行区人群有较好的预防效果,而每月服一次蒿甲醚的预防效果差。
Objective To observe the effect of artemether on the prevention of Schistosoma japonicum infection in the endemic area of schistosomiasis in Nanji County, Xinjian County, Jiangxi Province. Methods From May to November 2004, a pilot project was conducted in Nanshan Island, Nanxiao Township. The residents took half farming and semi-fishing as the industry, and residents aged 6 ~ 65 years were randomly divided into one group of artemether, two groups of artemether and the other two groups group. In the service of artemether 30d, after the test of stool schistosome eggs, a single dose of praziquantel 40mg / kg treatment. A group of artemether once every two weeks to take artemether 6mg / kg, a total of 13 times; artemether two groups once a month for taking artemether 6mg / kg, a total of 7 times; the control group to take the same dose of comfort Agent. Throughout the double-blind method for fecal examination, medication and observation. 40-60 days after the last dose for stool examination. Results The seroprevalence of serotonin in a group of 413 cases of artemether was 3.4%, which was significantly lower than that of control group (587 cases). The positive rate was 13.5% and the protection rate was 74.8% The infection rate was 10.5%, with the difference between the control group was not significant. Conclusions In the season of schistosomiasis transmission, artemether 6 mg / kg is given every half a month, which has a good preventive effect on people with severe endemic areas in the lake. The preventive effect of taking artemether once per month is poor.