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目的:研究幽门螺旋杆菌(HP)感染与缺铁性贫血(IDA)的相关性。方法:收集本院女性患者161例,采用金标法检测血清HP尿素酶抗体。分析HP阳性患者与阴性患者血红蛋白(Hb)、血清铁蛋白(SF)、平均红细胞体积(MCV)等指标。探讨HP与IDA的相关性以及清除HP在缺铁性贫血治疗中的必要性。结果:①161例女性IDA患者,HP阳性83例,HP感染率51.55%;对照组87例,HP阳性32例,感染率36.78%,两者相比具有统计学意义(P<0.05),女性IDA患者HP感染率明显高于健康女性;②HP表达阳性缺铁性贫血患者Hb及SF低于HP表达阴性患者,但无统计学意义。结论:幽门螺旋杆菌感染可能是缺铁性贫血的病因之一,对于临床上部分缺铁原因不明的患者,应该注意检测HP感染情况。
Objective: To study the correlation between Helicobacter pylori (HP) infection and iron deficiency anemia (IDA). Methods: A total of 161 female patients in our hospital were collected. The serum anti-urease antibody was detected by gold standard method. The indexes of hemoglobin (Hb), serum ferritin (SF) and mean corpuscular volume (MCV) in HP positive patients and negative patients were analyzed. To explore the correlation between HP and IDA and the necessity of eliminating HP in the treatment of iron deficiency anemia. Results: ① In 161 women with IDA, 83 were positive for HP and 51.55% for HP. 87 patients in the control group had 32 positive cases of HP, the infection rate was 36.78%. There was significant difference between the two groups (P <0.05) The HP infection rate of patients was significantly higher than that of healthy women. ②Hb and SF were lower in patients with negative expression of HP than those with negative expression of HP, but not statistically significant. Conclusions: Helicobacter pylori infection may be one of the causes of iron deficiency anemia. In patients with unknown causes of iron deficiency in clinical practice, attention should be paid to the detection of HP infection.