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用紫外分光光度法测定了15例正常人和37例肾综合征出血热（HFRS）患者在不同病期血、尿肽结合羟脯氨酸（PHP）的改变。37例HFRS患者血PHP均高于正常人（均P＜0．01）；尿PNP排出量（μmol／24h）在发热期、恢复期接近正常人（均P＞0．05），在低血压休克期、少尿期均低于正常人（P＜0．001），多尿期高于正常人（P＜0．05）。低血压休克期和少尿期血PHP与血BUN、Scr呈正相关（P＜0．001），尿PHP与血BUN、Scr呈负相关（P＜0．001）。结果提示血PHP、尿PHP可能是判断肾功能状态的新的敏感指标。
Ultraviolet spectrophotometry was used to determine the changes of serum and urinary peptide binding hydroxyproline (PHP) in 15 normal subjects and 37 HFRS patients at different stages. The plasma levels of PHP in 37 HFRS patients were significantly higher than those in normal controls (all P <0.01). Urinary PNP excretion (μmol / 24h) was similar to that in normal subjects during the fever and convalescent periods (all P> 0.05) Shock period, oliguria period were lower than normal (P <0.001), polyuria was higher than normal (P <0.05). There was a positive correlation between blood PHP and BUN and Scr, blood PHP in hypotension and oliguria (P <0.001), urinary PHP and BUN and Scr in blood (P <0.001). The results suggest that blood PHP, urinary PHP may be a new sensitive indicator of renal function.