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用高效液相色谱测定家兔给予没食子酸丙酯 ( PG) 1 5和 30 mg· kg-1后 1 .0 ,2 .0 ,3.5,7.0 ,1 0 .0 ,2 0 .0 ,30 .0和 40 .0 min的血浆浓度 ,分析所得血药浓度 -时间曲线符合二室开放性模型 .给家兔 ip双 -对硝基苯磷酸酯钠 ( BNPP) 3.4mg·kg-1,再 iv PG1 5和 30 mg·kg-1,所测 BNPP组与对照组 PG血浆浓度有显著不同 ,t1/2β,MRT以及AUC较对照组显著延长或增加 ,而 k10 及 Cl显著缩短 ,组间比较均 P<0 .0 5,P<0 .0 1 ,P<0 .0 0 1 .ivPG5.0 ,1 0 .0及 2 0 .0 min后其肝 ,肾和血桨中 PG浓度也较对照组增高 ,组间比较均 P<0 .0 5,结果表明 BNPP对 PG在家兔体内的代谢速率有明显影响 .
Rabbits were given 1.0, 2.0, 3.5, 7.0, 1.0, 2.0, 3.0, 30 days after administration of propyl gallate (PG) 15 and 30 mg · kg-1 by high performance liquid chromatography. 0 and 40. 0 min plasma concentration, the analysis of plasma concentration-time curve in line with the two-compartment open model to rabbit ip ip - p-nitrophenyl phosphate sodium (BNPP) 3.4mg · kg-1, and then iv PG1 5 and 30 mg · kg-1. There was a significant difference in PG plasma concentrations between the BNPP group and the control group. The t1 / 2β, MRT and AUC were significantly prolonged or increased compared with the control group, while k10 and Cl were significantly shortened P <0. 05, P <0. 01, P <0. 0 01.ivPG5.0, 1 0 .0 and 20 0 min after the liver, kidney and plasma PG concentrations were also compared with the control Group increased, P <0.05 compared between groups, the results showed that BNPP on the metabolism of PG in rabbits have a significant effect.