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目的本研究旨在探讨胃癌患者临床病理特征及其与预后的关系。方法对2005年3月～2008年3月在南方医科大学南方医院普通外科进行胃癌切除手术患者进行随访并进行回顾性分析。采用Kaplan-Meier生存率分析和Cox比例风险模型进行单因素和多因素分析。结果单因素分析显示TNM分期,组织学分型、肿瘤浸润深度、淋巴结转移与术后患者的生存率显著相关(P<0.05);性别、年龄、肿瘤部位及肿瘤分化程度不是影响患者预后的相关因素(P>0.05);Cox分析显示TNM分期是影响胃癌预后的独立因素(P<0.05)。结论TNM分期是影响胃癌患者预后的最重要因素;肿瘤类型、肿瘤浸润深度及淋巴结转移是判断胃癌预后的重要指标。
Objective The purpose of this study was to investigate the clinicopathological characteristics of patients with gastric cancer and its relationship with prognosis. Methods From March 2005 to March 2008, patients undergoing gastric cancer resection in General Surgery, Nanfang Hospital, Southern Medical University were followed up and analyzed retrospectively. Univariate and multivariate analyzes were performed using Kaplan-Meier survival analysis and Cox proportional hazards models. Results Univariate analysis showed that TNM staging, histological type, depth of tumor invasion and lymph node metastasis were significantly correlated with postoperative survival (P <0.05). The gender, age, tumor location and tumor differentiation were not the factors affecting the prognosis (P> 0.05). Cox analysis showed that TNM staging was an independent factor affecting the prognosis of gastric cancer (P <0.05). Conclusion TNM staging is the most important factor affecting the prognosis of patients with gastric cancer. The type of tumor, the depth of tumor invasion and lymph node metastasis are the important indexes to judge the prognosis of gastric cancer.