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目的：评价国产氟西汀治疗抑郁症的疗效及安全性。方法：将入组的１６例抑郁障碍病例随机分组进行双盲对照治疗。方法：氟西汀组９例（男性２例，女性７例，年龄４３±ｓ１０ａ），用氟西汀２０ｍｇ，ｐｏ，ｑｄ。阿米替林组７例（男性５例，女性２例，年龄３８±５ａ），用阿米替林７５ｍｇ，ｐｏ，ｂｉｄ。疗程６ｗｋ。结果：国产氟西汀组抗抑郁疗效与阿米替林组相当，在治疗的ｗｋ１，２，４，６末２组ＨＡＭＤ，ＨＡＭＡ，ＳＤＳ评分无显著差异。氟西汀的主要副作用为口干、便秘、视力模糊，但发生率较阿米替林低且较轻。结论：国产氟西汀疗效肯定，副作用少且轻。
Objective: To evaluate the efficacy and safety of domestic fluoxetine in the treatment of depression. Methods: Sixteen patients with depression were randomly assigned to double-blind control. Methods: Fluoxetine group 9 cases (2 males and 7 females, age 43 ± s10a), with fluoxetine 20mg, po, qd. Amitriptyline in 7 cases (5 males and 2 females, age 38 ± 5a), with amitriptyline 75mg, po, bid. Treatment 6wk. Results: The antidepressant efficacy of domestic fluoxetine group was comparable to that of amitriptyline group. There was no significant difference in the scores of HAMD, HAMA and SDS between the two groups treated wk1, 2, 4 and 6 at the end of treatment. The main side effects of fluoxetine are dry mouth, constipation, blurred vision, but the incidence is lower and lighter than amitriptyline. Conclusion: Domestic fluoxetine has definite curative effect with less side effects and light effects.