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为了评价单一大剂量地塞米松(Dx)治疗难治性、复发性MM的疗效和毒性反应,ECOG试验性研究给予Dx40mg每晨饭后口服1次,每周4天。连用8周。对客观有效者(OR),再以同样剂量每2周用药4天。治疗期间用SMZ co lg 2次/天和Mycelex糖丸10mg 3次/天,以预防感染。可评价客观疗效的32例均为Ⅲ期(Salmon and Durie),其中3例对以前所有治疗全无效,26例以前接受过多种治疗。结果,按ECOG标准13/32例(40％)获OR。在可评价是否主
To evaluate the efficacy and toxicity of a single high-dose dexamethasone (Dx) for the treatment of refractory, relapsed MM, the ECOG pilot study dosed with Dx40mg orally every morning for 4 days. Used for 8 weeks. The objective effective (OR), and then the same dose every 2 weeks for 4 days. Treatment with SMZ co lg 2 times a day and Mycelex sugar pills 10mg 3 times a day to prevent infection. Thirty-two patients were evaluated for objective efficacy in all three patients (Salmon and Durie), three of whom were ineffective in all previous treatments and 26 previously had multiple treatments. Results, according to the ECOG standard 13/32 cases (40%) OR. In the evaluation of whether the main