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本研究观察高胆固醇血症和实验性动脉粥样硬化形成对必需微量元素Cu、Zn、Cr、Mn、Se代谢的影响。将22只家兔随机分为动脉粥样硬化造型组和对照组。造型组每只家兔每天喂胆固醇0.5g,该组在形成高胆固醇血症和动脉粥样硬化的4个月过程中,血清Cu均值逐渐升高,Zn逐渐降低,Ca/Zn比值逐渐增大,前后对比差异显著。对照组血清Cu、Zn无显著变化。两组的血清Cu、Zn同次测定值对比有显著或高度显著差异。血清Cr、Mn、Se均无显著变化。相关性检验证实,造型组血清胆固醇均值与血清Ca均值无显著相关(P>0.5),而与血清Zn均值呈高度负相关(P<0.01)。结果表明,在形成实验性动脉粥样硬化的过程中,高胆固醇食物及高胆固醇血症可引起血清Zn降低,又通过锌铜拮抗,使血清Cu升高。
This study was to investigate the effects of hypercholesterolemia and experimental atherosclerosis on the metabolism of essential trace elements Cu, Zn, Cr, Mn and Se. Twenty-two rabbits were randomly divided into atherosclerosis modeling group and control group. In the model group, every rabbit fed 0.5g cholesterol every day. During the 4 months of hypercholesterolemia and atherosclerosis, the serum Cu mean value gradually increased, Zn decreased gradually, and Ca / Zn ratio gradually increased , Significant difference between before and after comparison. The control group serum Cu, Zn no significant change. There was significant or highly significant difference between the two groups in the determination of serum Cu and Zn. Serum Cr, Mn, Se were no significant changes. Correlation test confirmed that the model group, serum mean serum cholesterol and serum Ca was no significant correlation (P> 0.5), and the serum Zn was highly negative correlation (P <0.01). The results show that in the process of forming experimental atherosclerosis, high cholesterol foods and hypercholesterolemia can cause serum Zn decreased, but also through the copper and copper antagonism, serum Cu increased.