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目的研究纳洛酮治疗肺性脑病的临床疗效、作用机制,更好的服务于临床。方法选取南阳市肺性脑病患者55例,随机分为对照组20例和治疗组35例。两组基本对症治疗方法相同,治疗组另给予纳洛酮0.4 mg加生理盐水20 ml静脉注射后,以后为纳洛酮0.8 mg加入5%葡萄糖注射液500 ml静脉滴注,1次/d,观察疗效3 d。结果治疗组治疗后30 min～3 d,患者血气指标多数转为正常,有效率为90.5%,无不良反应发生。对照组有效率为60.0%。治疗组有效率显著高于对照组,差异有统计学意义(P<0.05)。结论纳洛酮治疗肺性脑病疗效确切,查阅文献证明,作用机制明确。
Objective To study the clinical efficacy and mechanism of naloxone in the treatment of pulmonary encephalopathy and to better serve the clinic. Methods Fifty-five patients with pulmonary encephalopathy in Nanyang were randomly divided into control group (20 cases) and treatment group (35 cases). Two groups of the same symptomatic treatment were the same, the treatment group was given another 0.4 mg Naloxone plus normal saline 20 ml intravenous injection, after naloxone 0.8 mg 5% glucose injection 500 ml intravenous infusion, 1 / d, Observation of efficacy 3 d. Results After treatment for 30 min to 3 d, most of the patients had normal blood gas indexes, with an effective rate of 90.5%. No adverse reactions occurred. The control group was 60.0%. The treatment group efficiency was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion Naloxone treatment of pulmonary encephalopathy exact effect, access to literature to prove that the mechanism of action clear.