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目的观察硫酸镁联合硝苯地平和酚妥拉明治疗妊娠高血压综合征(妊高症,PIH)的临床疗效。方法 105例PIH患者,随机分为观察组(联合用药)53例,对照组(单一用药)52例。其中对照组单用25%硫酸镁静脉滴注;观察组采用联合用药治疗,即在对照组静脉滴注25%硫酸镁的基础上,给予酚妥拉明同时口服硝苯地平控释片治疗。两组患者均治疗7 d。观察治疗效果。结果治疗7 d后,观察组总有效率96.2%,对照组总有效率75.0%,观察组临床疗效明显优于对照组,组间比较差异具有统计学意义(P<0.05),两组治疗后平均动脉压(MAP)、红细胞比容(HCT)、24 h尿蛋白定量(PRO-U)及脐动脉血流速度峰谷比(S/D)较治疗前均有明显改善,组内比较差异有统计学意义(P<0.05),两组治疗后各观察指标组间比较,差异具有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平和酚妥拉明治疗PIH,降压平稳,解痉作用强,临床疗效显著,可有效减少围生期并发症的发生。
Objective To observe the clinical efficacy of magnesium sulfate combined with nifedipine and phentolamine in the treatment of pregnancy induced hypertension (PIH). Methods A total of 105 patients with PIH were randomly divided into observation group (combination therapy) 53 cases and control group (single therapy) 52 cases. The control group was intravenously dripped with 25% magnesium sulfate alone. The observation group was treated with combination therapy, namely, the control group was treated with intravenous drip of 25% magnesium sulfate and phentolamine and controlled release nifedipine. Both groups were treated for 7 days. Observe the effect of treatment. Results After 7 days of treatment, the total effective rate was 96.2% in the observation group and 75.0% in the control group. The clinical efficacy of the observation group was significantly better than that of the control group. The differences between the two groups were statistically significant (P <0.05) Mean arterial pressure (MAP), hematocrit (HCT), 24-hour urinary protein content (PRO-U) and umbilical artery blood flow velocity ratio (S / D) were significantly improved compared with those before treatment, There was statistical significance (P <0.05). There was significant difference between the two groups after treatment (P <0.05). Conclusion Magnesium sulfate combined with nifedipine and phentolamine treatment of PIH, stable blood pressure, strong antispasmodic effect, significant clinical effect, which can effectively reduce the incidence of perinatal complications.