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目的:以Al.Chaer内脏高敏感理论为基础,探讨一种建立大鼠肠易激综合征模型的新方法。方法:SD成年雄性4周龄大鼠50只,每天给予直肠内球囊扩张刺激,3周后对其进行直肠扩张,评估其腹部收缩反射(AWR)阈值,并测定大鼠腹壁肌电活动,验证其敏感性。结果:与成年期无刺激对照组(C组)和成年期直肠内球囊非扩张性刺激组(B组)相比,直肠扩张时,成年期直肠内球囊扩张刺激组大鼠(A组)拱起背部和抬起腹部时的容量阈P<0.05、P<0.05、P<0.05;与C组相比,分别为P<0.01、P<0.05和P<0.05)。结论:成年SD大鼠的直肠内球囊扩张刺激可以引起内脏敏感性增高,其所引起的应激可导致肠动力紊乱,引起肠易激综合征。
OBJECTIVE: To establish a new method for establishing a model of irritable bowel syndrome in rats based on Al. Chaer visceral hypersensitivity theory. Methods: Fifty SD male adult 4-week-old rats were given daily rectal balloon dilatation stimulation. Rectal dilatation was performed 3 weeks later to evaluate their abdominal contractive reflex (AWR) threshold and to determine the myoelectric activity of the abdominal wall, Verify its sensitivity. RESULTS: Compared with adult non-irritating control group (C group) and adult rectum balloon non-dilating stimulation group (B group), in rectal dilatation, adult rectum balloon dilatation stimulation group (A group (P <0.05, P <0.05; P <0.01, P <0.05 and P <0.05, respectively, compared with group C). Conclusion: The rectal balloon dilatation in adult Sprague-Dawley rats can induce visceral hypersensitivity. The stress induced by it may lead to intestinal motility disorder and irritable bowel syndrome.