目的:探讨解脲脲原体(UU)感染与早产儿肺损伤的关系。方法:采集2011年1月至2012年10月深圳市宝安区妇幼保健院新生儿科收治的早产儿的胃液,行UU核酸定量检测,将其中69例阳性患儿作为阳性组,另选70例阴性患儿作为阴性组,比较两组患儿胎膜早破和支气管肺发育不良(BPD)发生率、胸片恢复正常所需时间及血气异常、氧疗、机械通气比例。结果:阳性组胎膜早破发生率为53.6%,胸片恢复正常时间(11.0±7.6)d,血气异常、氧疗、机械通气比例分别为46.4%、60.9%、31.9%;阴性组胎膜早破发生率为45.7%,胸片恢复正常时间(5.5±4.9)d,血气异常、氧疗、机械通气比例分别为28.6%、35.7%、11.4%,两组比较差异均有统计学意义(P<0.05);阳性组BPD发生率为4.3%,阴性组为1.4%,两组比较差异无统计学意义(P>0.05)。结论:定量检测胃液UU核酸对诊治UU感染具有指导意义,且UU感染与早产儿急(慢)性肺损伤密切相关。 Objective: To investigate the relationship between UU infection and lung injury in premature infants. Methods: The gastric juice of premature infants admitted to Bao’an District Maternal and Child Health Hospital of Shenzhen City from January 2011 to October 2012 was collected for quantitative detection of UU nucleic acid. Among them, 69 positive children were considered as positive group, 70 were negative Children as a negative group, compared the incidence of premature rupture of membranes and bronchopulmonary dysplasia (BPD) in both groups, the time required for chest radiography to return to normal and blood gas abnormalities, oxygen therapy, mechanical ventilation ratio. Results: The incidence of premature rupture of membranes was 53.6% in positive group and 11.0 ± 7.6 days in normal chest radiography. The abnormal blood gas, oxygen therapy and mechanical ventilation were 46.4%, 60.9% and 31.9% respectively. Negative fetal membranes The rate of premature rupture was 45.7%, the duration of chest X-ray returned to normal (5.5 ± 4.9) d, blood gas abnormalities, oxygen therapy and mechanical ventilation were 28.6%, 35.7% and 11.4% respectively. There were significant differences between the two groups P <0.05). In the positive group, the incidence of BPD was 4.3%, while the negative group was 1.4%. There was no significant difference between the two groups (P> 0.05). Conclusion: Quantitative detection of UU nucleic acid in gastric juice is of guiding significance in the diagnosis and treatment of UU infection. UU infection is closely related to acute (slow) lung injury in premature infants.