[目的]5-甲氧甲基-2,3-吡啶二羧酸是合成除草剂甲氧咪草烟的关键中间体,具有重要的研究和生产价值。[方法]以马来酸二乙酯为起始原料,经过羟胺取代、脱水、加成环合和水解制成5-甲氧甲基-2,3-吡啶二羧酸。[结果]反应总收率42.4%,含量95.6%。[结论]该路线可以作为工业生产路线。 [Objective] 5-Methoxymethyl-2,3-pyridinedicarboxylic acid is a key intermediate for the synthesis of imazamox and has important research and production value. [Method] Diethyl maleate was used as the starting material to make 5-methoxymethyl-2,3-pyridinedicarboxylic acid by hydroxylamine substitution, dehydration, addition cyclization and hydrolysis. [Result] The total reaction yield was 42.4% and the content was 95.6%. [Conclusion] The route can be used as industrial production route.