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作者采用上午8时血清皮质醇浓度、皮质醇昼夜节律及2h ACTH试验三项指标。对54例激素敏感型肾病患儿的肾上腺皮质功能进行了测定和分析。结果发现患儿在发病期肾上腺皮质功能降低,其表现不仅有基础血清皮质醇浓度降低,还有皮质醇昼夜分泌节律紊乱和肾上腺皮质储备功能低下。上午8时血清皮质醇浓度:肾病患儿与50例健康儿童(352±162 nmol/L)比较,P<0.02或P<0.01;而肾病患儿频复发组与非频复发组分别为128.4±107.3 nmol/L及236.8±113.4nmol/L,差异有显著性(P<0.05);初发和复发肾病患儿中,激素治疗高敏组和激素治疗低敏组的浓度分别为150.8±92.2nmol/L及242.4±148.3
The authors used 8:00 am serum cortisol concentration, circadian rhythm of cortisol and 2h ACTH test three indicators. The adrenocortical function of 54 children with hormone-sensitive nephropathy was measured and analyzed. The results showed that children with adrenal cortical dysfunction during the onset of the performance of its performance not only the basis of serum cortisol concentration decreased, as well as circadian rhythm of cortisol secretion and adrenal insufficiency. The serum cortisol concentration at 8 AM was significantly higher than that in 50 healthy children (352 ± 162 nmol / L) (P <0.02 or P <0.01), while the incidence of nephropathy was 128.4 ± 107.3 nmol / L and 236.8 ± 113.4 nmol / L, respectively (P <0.05). The concentrations of hormone-sensitive hypersensitivity and hormone-treated hypersensitivity in children with primary and recurrent nephropathy were 150.8 ± 92.2nmol / L and 242.4 ± 148.3