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为了了解使用特布他林2周是否会发生支气管扩张作用减弱，以及酮替芬能否有效地预防这种情况的发生。采用公开交叉、对比的方法观察10例处于稳定期的轻度慢性哮喘患者单纯口服特布他林2周和先口服酮管芬6周后加服特布他林2周时的肺功能变化。结果显示连续口服特布他林10dFEV1改善率就由开始时的15．9％降至8．9％（P＜0．05），而先服用酮替芬6周再加取特布他林2周就不会出现FEV1改善伞下降（P＞0．05）。这说明连续口服特布他林10d就会出现支气管扩张作用减弱，长期使用酮替芬能有效地预防特布他林支气管扩张作用减弱的发生。
In order to find out whether bronchodilation was attenuated with terbutaline for 2 weeks and whether ketotifen could effectively prevent this from happening. The open cross-comparison was used to observe the changes of lung function in 10 patients with mild chronic asthma who were in stable phase at 2 weeks of oral inhalation of terbutaline and the first oral administration of ketoprofen for 6 weeks. The results showed that the rate of improvement of 10dFEV1 for oral continuous oral administration of terbutaline decreased from 15.9% at the beginning to 8.9% (P <0.05), while that of ketotifen followed by taking terbutaline 2 There was no reduction in FEV1-treated umbrella (P> 0.05). This shows that continuous oral administration of terbutaline 10d will appear bronchiectasis weakened, long-term use of ketotifen can effectively prevent the weakening of bronchodilator effect of terbutaline.