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目的：观察碱性成纤维细胞生长因子在人颌面部骨折愈合过程中的表达及量的变化。方法：于颌面部骨折的患者行切开复位内固定术时，取骨断端间骨痂，利用ＡＢＣ免疫组织化学方法检测了骨折后不同时间碱性成纤维细胞生长因子在骨痂组织中的分布。结果：在骨折修复初期的骨痂中，新生骨基质、未分化间充质细胞、成骨细胞、幼稚的软骨细胞、骨细胞及血管内皮细胞的免疫组化染色均为强阳性。随着骨化的进行及软骨的成熟，成熟钙化的骨基质、处于分化末期的肥大的软骨细胞染色为阴性，成骨细胞、骨细胞及血管内皮细胞仍有部分呈阳性反应，但阳性着色的细胞数及阳性反应程度均较前明显下降。结论：碱性成纤维细胞生长因子参与了人颌面部骨折修复的全过程，在骨折愈合中发挥着重要的作用。
OBJECTIVE: To observe the expression of bFGF and its changes during fracture healing in human maxillofacial region. Methods: In patients undergoing maxillofacial fracture underwent open reduction and internal fixation, the bony callus was removed. The ABC immunohistochemical method was used to detect the expression of basic fibroblast growth factor in callus tissue at different time after fracture Distribution. RESULTS: Immunohistochemical staining of newly born bone matrix, undifferentiated mesenchymal cells, osteoblasts, immature chondrocytes, bone cells and vascular endothelial cells were all strongly positive in the early callus repair. With the progression of ossification and cartilage maturation, mature calcified bone matrix, hypertrophic chondrocytes in the late stage of differentiation were stained negative, some of osteoblasts, osteocytes and vascular endothelial cells were still positive, but the positive staining The number of cells and the positive reaction were significantly lower than before. Conclusion: Basic fibroblast growth factor participates in the whole process of human maxillofacial fracture repair and plays an important role in fracture healing.