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目的分析超声波治疗对后循环缺血患者临床疗效及椎动脉血流影响。方法选择诊断为后循环缺血患者228例,随机分为研究组与对照组,每组114例。对照组患者依据2006年中国后循环缺血专家共识以及颅内动脉粥样硬化诊疗指南给予内科药物治疗,以舒血宁注射液10 ml+0.9%氯化钠溶液250 ml静脉滴注,1次/d,连续治疗14 d。研究组在对照组治疗基础上加用超声波治疗。分别与治疗前、后采用彩色超声多普勒检测椎动脉颅外段收缩期峰值流速(PSV)、舒张期末流速(EDV)、阻力指数(RI)、血流加速时间(T),比较2组患者参数,采用美国国立卫生研究院神经功能缺损程度评分量表(NIHSS)作为疗效判断标准,比较2组患者临床疗效。结果治疗前,2组患者PSV、EDV、RI、T的差异无统计学意义(P>0.05)。治疗后,2组患者椎动脉颅外段PSV、EDV增加,RI降低、血流加速时间减低,与治疗前比较,差异均有统计学意义(P<0.05)。研究组改善幅度优于对照组,差异有统计学意义(P<0.05)。研究组临床疗效高于对照组,差异有统计学意义(P<0.05)。结论超声波辅助治疗后循环缺血患者可以明显降低颅外段椎动脉血流阻力,缩短血流加速时间,增加椎动脉内血流量,改善患者临床症状,提高临床疗效。
Objective To analyze the clinical effect of ultrasound treatment on posterior circulation ischemia and the influence of vertebral artery blood flow. Methods A total of 228 cases of post-ischemic patients were selected and randomly divided into study group and control group, with 114 cases in each group. Patients in the control group were given medical treatment according to the consensus of the experts on posterior circulation ischemia in 2006 and the guidelines for diagnosis and treatment of intracranial atherosclerosis. The patients in the control group were given intravenous infusion of 250 ml Shuxuening injection + 0.9% sodium chloride solution once, / d, continuous treatment 14 d. Study group in the control group based on the addition of ultrasound treatment. The PSV, EDV, RI and T of the extracranial extracranial segments of vertebral artery were measured respectively by color Doppler ultrasound before and after treatment. The blood flow acceleration time (T) The parameters of the patients were evaluated by the National Institutes of Health neurological deficit score (NIHSS) as the criterion of efficacy. The clinical efficacy of the two groups were compared. Results Before treatment, there were no significant differences in PSV, EDV, RI, T between the two groups (P> 0.05). After treatment, the PSV, EDV, RI, and acceleration time of extracranial segments of vertebral artery in both groups were significantly decreased (P <0.05) compared with those before treatment. The research group improved better than the control group, the difference was statistically significant (P <0.05). The clinical efficacy of the study group was higher than that of the control group, the difference was statistically significant (P <0.05). Conclusions Ultrasound-assisted treatment of patients with ischemic reperfusion can significantly reduce the extracranial vertebral artery blood flow resistance, shorten the blood flow acceleration time, increase the blood flow in the vertebral artery, improve clinical symptoms and improve clinical efficacy.