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目的:观察沙克1号(SCAE)和环磷酰胺(CP)联合使用时,对肿瘤抑制的复合效应。方法:S_(180)移植瘤接种的小鼠分别给予SCAE,CP及SCAE+CP后,测定抑瘤率等。结果:300mg/(kc.d)的SCAE,5～10mg/(kg.d)的CP对肿瘤生长均无明显的抑瘤作用,两者合用后出现明显的抑瘤作用.结论:SCAE与小剂量CP联合使用能明显的抑制肿瘤生长,并可使CP毒副作用减小或消失.
OBJECTIVE: To observe the combined effect of SCAE and cyclophosphamide (CP) on tumor inhibition. Methods: S_(180) tumor-inoculated mice were given SCAE, CP, and SCAE+CP, and the tumor inhibition rate was measured. RESULTS: The 300 mg/(kc.d) SCAE and the 5 to 10 mg/(kg.d) CP had no significant anti-tumor effect on tumor growth. The combination of the two showed significant anti-tumor effect. Conclusion: SCAE and small Combined use of doses of CP can significantly inhibit tumor growth, and can reduce or eliminate CP side effects.