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目的研究止凝血功能在急慢性白血病中的变化。方法对64例白血病患者分组进行纤维蛋白原(Fg:Ag),血管性假血友病因子(vWF:Ag),蛋白C(PC),组织纤溶酶原激活物(t-PA:A)及其抑制物活性(PAI:A),纤溶酶原活性(PLG:A),a2-纤溶酶抑制物活性(a2-PI:A),纤维蛋白原降解产物D-二聚体(D-D),内皮素-1(ET-1)的检测。结果急性白血病组的Fg:Ag增高而a2-PI:A减少(P<0.01或P<0.05);慢性白血病患者Fg:Ag增高而a2-PI:A减少(P<0.05);其余指标改变无统计学意义。结论急性白血病患者均存在高凝状态。急性白血病的纤溶亢进和内皮细胞受损,除了引起出血,还可能与疾病的浸润转移有关。
Objective To study the changes of coagulation function in acute and chronic leukemia. Methods 64 patients with leukemia were divided into fibrinogen (Fg: Ag), von Willebrand factor (vWF: Ag), protein C (PC), and tissue plasminogen activator (t-PA: A). And its inhibitor activity (PAI:A), plasminogen activity (PLG:A), a2-plasmin inhibitor activity (a2-PI:A), fibrinogen degradation product D-dimer (DD ), Endothelin-1 (ET-1) detection. Results Fg:Ag increased and a2-PI:A decreased in acute leukemia group (P<0.01 or P<0.05); Fg:Ag increased and a2-PI:A decreased in chronic leukemia patients (P<0.05); Statistical significance. Conclusion All patients with acute leukemia have hypercoagulable state. The hyperfibrinolysis of acute leukemia and the damage of endothelial cells, besides causing bleeding, may also be related to the infiltration and metastasis of the disease.