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目的分析克氏综合征患者血清性激素水平,为临床诊断克氏综合征提供参考依据。方法随机收集45例克氏综合征患者及50例健康男性对照,检测所有对象的血清性激素水平,进行比较分析。结果克氏综合征患者组血清卵泡刺激素和黄体生成素分别为(27.1±6.9)IU/L和(21.6±7.9)IU/L,均明显高于正常对照组(P<0.01);克氏综合征组睾酮(13.5±6.9)mmol/L,明显低于正常对照组(P<0.05);血清泌乳素在两组间差异无显著性(P>0.05)。结论血清性激素测定对克氏综合征的诊断有重要意义,患者存在明显的“两高一低”现象,即卵泡刺激素和黄体生成素升高,睾酮降低,可以用来提示克氏综合征并最终通过核型分析进行确诊。
Objective To analyze the serum levels of sex hormones in patients with Klinefelter’s syndrome and provide a reference for the clinical diagnosis of Klinefelter’s syndrome. Methods A total of 45 patients with Klinefelter’s syndrome and 50 healthy controls were collected randomly to detect the levels of serum sex hormones in all the subjects for comparative analysis. Results Serum follicle stimulating hormone and luteinizing hormone were (27.1 ± 6.9) IU / L and (21.6 ± 7.9) IU / L in patients with Klinefelter syndrome, respectively, which were significantly higher than those in the control group (P <0.01) Syndrome group testosterone (13.5 ± 6.9) mmol / L, was significantly lower than the normal control group (P <0.05); serum prolactin in the two groups showed no significant difference (P> 0.05). Conclusions Serum sex hormone test is of great significance for the diagnosis of Klinefelter’s syndrome. The patients have obvious “high and low one” phenomenon, that is, elevated follicle stimulating hormone and luteinizing hormone and decreased testosterone may be used to prompt Klinefelter’s syndrome Sign and eventually confirmed by karyotyping.