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为探讨ｐ２１、ＰＣＮＡ在喉鳞癌中表达及其与临床的关系，采用免疫组化ＬＳＡＢ方法对３７例喉原发性鳞癌、癌旁１．０ｃｍ组织及２０例声带息肉组织进行ｐ２１和ＰＣＮＡ的检测，结果显示：ｐ２１表达定位于胞浆，癌旁组中有３例软骨细胞出现胞核阳性。喉癌组与癌旁组及声带息肉组的表达率相比较，Ｐ＜０．０５。组织分化高者ｐ２１表达高，组织分化低者ＰＣＮＡ表达高，高、低分化者表达率相比较，Ｐ均＜０．０５。但ｐ２１与ＰＣＮＡ二者无明显负相关。有颈淋巴结转移者的ＰＣＮＡ表达明显高于未转移者，Ｐ＜０．０５。作者认为，ｐ２１和ＰＣＮＡ在喉癌细胞的生长调控中可能起着重要作用。
To investigate the expression of p21 and PCNA in laryngeal squamous cell carcinoma and its clinical significance, immunohistochemical LSAB method was used to detect the expression of p21 and PCNA in 37 cases of primary laryngeal squamous cell carcinoma, 1.0 cm of paraneoplastic tissues and 20 cases of vocal cord polyp tissues. The results showed that: p21 expression located in the cytoplasm, paracancer group in 3 cases of chondrocytes appeared nucleus positive. Laryngeal cancer group and paracancer group and vocal cord polyps expression rate compared, P <0.05. The expression of p21 was higher in patients with higher differentiation and higher in patients with poor differentiation compared with those in patients with high differentiation and poor differentiation (all P <0.05). However, there was no significant negative correlation between p21 and PCNA. PCNA expression in patients with cervical lymph node metastasis was significantly higher than those without metastasis, P <0.05. The authors believe that p21 and PCNA may play an important role in the regulation of the growth of laryngeal carcinoma cells.