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目的:了解西安市三甲综合医院耐甲氧西林金黄色葡萄球菌(MRSA)qacA/B基因的携带情况,以便掌握其对消毒剂的耐药情况。方法:收集临床分离的152株耐甲氧西林金黄色葡萄球菌,采用聚合酶链反应检测qacA/B基因,并将qacA/B基因扩增产物进行测序,测序结果进行比对。结果:152株耐甲氧西林金黄色葡萄球菌中有11株检出qacA/B阳性,qacA/B携带率7.2%;测序结果比对发现,4株qacA的基因编码序列同一位点均有一个碱基发生突变(C→T),苏氨酸突变为异亮氨酸。结论:该地区临床分离的耐甲氧西林金黄色葡萄球菌中qacA/B携带率相对较低,但也存在抵抗消毒剂的风险,临床应加强消毒剂使用的管理,阻止MRSA的传播,减少感染的发生。
Objective: To understand the carrying status of qacA / B gene of methicillin-resistant Staphylococcus aureus (MRSA) in Xi’an Jiaotong General Hospital in order to master its resistance to disinfectants. Methods: 152 strains of methicillin-resistant Staphylococcus aureus were collected. The qacA / B gene was detected by polymerase chain reaction (PCR) and the amplified product of qacA / B gene was sequenced. The sequencing results were compared. Results: Of the 152 strains of methicillin-resistant Staphylococcus aureus, 11 strains were positive for qacA / B, and the qacA / B carrier rate was 7.2%. Comparing the sequencing results, it was found that all four qacA genes had one qACA / Base mutation (C → T), threonine mutation isoleucine. CONCLUSIONS: The qacA / B carrier rate of methicillin-resistant Staphylococcus aureus in clinical isolates is relatively low in this area, but there is also a risk of resistance to disinfectants. Clinically, the administration of disinfectants should be strengthened to prevent the spread of MRSA and reduce the infection happened.