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目的评价硫酸镁联合硝苯地平治疗妊娠高血压综合征(妊高征)的疗效。方法将妊高征患者100例动态随机化法分为试验组和对照组各50例,其中对照组患者给予硫酸镁治疗,试验组患者则给予硝苯地平联合硫酸镁治疗,对2组患者经相关治疗后的血压水平、24 h尿蛋白、疗效及并发症进行观察分析。结果 2组患者经相关治疗后血压水平及24 h尿蛋白量均较治疗前明显改善(P<0.05),且试验组患者的血压水平及24 h尿蛋白量改善程度优于对照组,差异均有统计学意义(P<0.05)。试验组患者治疗的总有效率为92.00%明显高于对照组的74.00%,差异有统计学意义(χ2=5.741,P<0.05)。2组患者的并发症发生率对比差异无统计学意义(χ2=0.154,P>0.05)。结论妊高征患者接受硫酸镁联合硝苯地平治疗,可较好改善患者的血压水平,且安全性较高,意义重大。
Objective To evaluate the efficacy of magnesium sulfate combined with nifedipine in the treatment of pregnancy induced hypertension (PIH). Methods One hundred patients with PIH were divided into trial group and control group with 50 cases in each group. The patients in the control group were treated with magnesium sulfate. The patients in the test group were treated with nifedipine and magnesium sulfate. After treatment, blood pressure, 24 h urinary protein, efficacy and complications were observed and analyzed. Results The blood pressure and 24 h urinary protein levels of the two groups were significantly improved after treatment (P <0.05), and the levels of blood pressure and 24 h urinary protein in the experimental group were better than those in the control group There was statistical significance (P <0.05). The total effective rate of the treatment group was 92.00%, which was significantly higher than that of the control group (74.00%), the difference was statistically significant (χ2 = 5.741, P <0.05). There was no significant difference in complication rates between the two groups (χ2 = 0.154, P> 0.05). Conclusion Pregnancy-induced hypertension patients treated with magnesium sulfate combined with nifedipine, can better improve the patient’s blood pressure level, and the safety is high, of great significance.