Angew.Chem.Int.Ed.2013,52,10245~10249含有C(3)位手性季碳中心的吲哚酮类化合物广泛存在于医药中间体和具有生物活性的天然产物中,并具有非常高的药理活性,而3-单取代-2-吲哚酮的不对称α-芳基化反应是获得含手性季碳中心的吲哚酮最有效最简单的方法之一.目前主要通过Pd,Cu等后过渡金属参与的氧化加成、还原消除、转金属化反应来实现,但常具有一定的底物局 Angew.Chem.Int.Ed.2013,52,10245 ~ 10249 Indolones containing C (3) chiral quaternary carbon centers are widely found in pharmaceutical intermediates and bioactive natural products and have very high High pharmacological activity, and the asymmetric α-arylation of 3-monosubstituted 2-indolones is one of the most effective and simplest methods for obtaining indolones containing chiral quaternary carbon centers. At present, Pd , Cu and other post-transitional metals involved in the oxidation addition, reduction and elimination, turn the metal reaction to achieve, but often have some substrate