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目的:研究CCAAT/增强子结合蛋白β(C/EBPβ)在新疆汉族妇女子宫颈鳞癌组织中的表达及病理分级的意义。方法:采用免疫组织化学S-P法对33例子宫颈鳞癌组织、37例慢性子宫颈炎组织中C/EBPβ蛋白质的表达进行检测。结果:新疆汉族妇女子宫颈鳞癌组织与慢性子宫颈炎C/EBPβ蛋白质的表达相比较明显降低,差异有统计学意义(P<0.05);不同病理分级的子宫鳞癌组织中,C/EBPβ蛋白质的表达在高分化癌高于中分化癌,中分化癌高于低分化癌,差异有统计学意义(P<0.05)。结论:C/EBPβ蛋白质表达在新疆汉族子宫颈鳞癌不同病理分级表达不同,可能用于子宫颈癌诊断。
Objective: To investigate the expression of CCAAT / enhancer binding protein β (C / EBPβ) in cervical squamous cell carcinoma of the Han women in Xinjiang and its clinical significance. Methods: The expressions of C / EBPβ protein in 33 cases of cervical squamous cell carcinoma and 37 cases of chronic cervicitis were detected by immunohistochemical S-P method. Results: The expression of C / EBPβprotein in cervical squamous cell carcinoma of Chinese Han women was significantly lower than that of chronic cervicitis (P <0.05), and the expression of C / EBPβprotein in cervical squamous cell carcinoma of different pathological grades The expression was higher in well-differentiated cancer than in moderately-differentiated cancer, moderately-differentiated cancer was higher than in poorly-differentiated cancer, the difference was statistically significant (P <0.05). Conclusion: The expression of C / EBPβ protein is different in different pathological grades of cervical squamous cell carcinoma in Xinjiang Han people, which may be used in the diagnosis of cervical cancer.