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抗胆碱药具有广泛的临床用途,但目前尚无满意的测定中枢药物反应的实验动物模型.本实验建立了猫平衡木操作式条件反射法测定其中枢药物反应. 实验方法:家猫,散养,定时定量给食,每日上午以肉为诱饵在宽2.5cm、高1.3m、总长度7.5m、终点为食盘的环形平衡木上训练行走.猫能在10天左右学会,行走和走完十圈所需时间趋稳定.训练成功后可开始给药,观察给药后30min和60min家猫在平衡木上行走的行为表现和走完十圈的时间,根据评分标
Anticholinergic drugs have a wide range of clinical applications, but there is no satisfactory experimental animal model for the determination of the central drug response.In this study, cat central balance beam operated conditioned reflex method was used to determine the central drug response.Methods: Domestic cats, free-range, regular quantitative Feeding, daily morning with meat bait width 2.5cm, height 1.3m, a total length of 7.5m, the end of the food tray ring balance wood training to walk cats can learn about 10 days, walk and finish ten laps Take time to stabilize.Training can be started after the success of training to observe the behavior of cats walking on the balance beam at 30min and 60min after administration and the time to finish ten laps,