目的了解内蒙古某地区男性超重肥胖和饮酒对血尿酸(SUA)水平的影响。方法 2006年9月至2007年3月,抽取在锡林郭勒盟医院健康体检的630名城区男性和179名农区男性为调查对象进行横断面调查,通过问卷调查、体格检查和实验室检测分别获取调查对象饮酒、身高、体重、腰围和SUA水平,按照日均饮酒量、过量饮酒频次、饮酒种类定义饮酒情况,通过体质指数(BMI)和腰围反映超重或肥胖和中心型肥胖,采用协方差分析、多因素logistic回归分析,探讨超重肥胖和饮酒对SUA的影响及其之间的交互作用。结果体重正常组、超重组、肥胖组的SUA水平依次升高,分别为(315.6±81.0)、(350.4±81.6)、(376.8±82.2)μmol/L,差异有统计学意义(P<0.01);超重和肥胖组的高尿酸血症(HUA)的检出率分别为19.5%、33.1%,高于正常体重组(8.3%),调整后的OR值分别为2.71(95%CI:1.68~4.39)和5.47(95%CI:3.31~9.04)。超量饮酒者SUA水平([360.6±85.8)μmol/L]高于从不饮酒者和适量饮酒者[分别为(317.4±93.0)、(343.2±78.6)μmol/L],差异均有统计学意义(P<0.05);每周过量饮酒1~2次者的SUA水平([355.2±81.0)μmol/L]高于从不饮酒者和饮酒但从不过量者([334.2±78.0)μmol/L],差异均有统计学意义(P<0.05)。中心型肥胖且超量饮酒者HUA的患病危险高,OR值为3.46(95%CI:1.65~7.25)。未发现超重或肥胖和饮酒对SUA水平影响的交互作用。结论超重或肥胖是HUA的独立危险因素,过量饮酒会导致SUA水平的升高。建议我国北方男性控制或降低体重,限制饮酒,以预防HUA和痛风的发生。 Objective To understand the effect of overweight, obesity and alcohol consumption on serum uric acid (SUA) in some areas of Inner Mongolia. Methods From September 2006 to March 2007, 630 urban males and 179 rural males from a health examination at Xilin Gol League Hospital were selected as the subjects for cross-sectional survey. Surveys were obtained through questionnaire, physical examination and laboratory tests The subjects’ alcohol consumption, height, weight, waist circumference and SUA level were defined according to daily drinking amount, overdrinking frequency and drinking type, and overweight or obesity and central obesity by body mass index (BMI) and waist circumference were analyzed by covariance analysis. Multivariate logistic regression analysis was performed to investigate the effects of overweight and obesity and drinking on SUA and their interactions. Results The levels of SUA in normal weight group, overweight group and obesity group were (315.6 ± 81.0), (350.4 ± 81.6) and (376.8 ± 82.2) μmol / L respectively, with statistical significance (P <0.01) The prevalence of hyperuricemia (HUA) in overweight and obesity groups was 19.5% and 33.1%, respectively, higher than that of normal weight group (8.3%). The adjusted odds ratio (OR) was 2.71 4.39) and 5.47 (95% CI: 3.31 to 9.04). The level of SUA was significantly higher in overdosage drinkers ([(360.6 ± 85.8) μmol / L vs [317.4 ± 93.0 vs 343.2 ± 78.6] μmol / L, respectively] (P <0.05). SUA level (355.2 ± 81.0 μmol / L) in those who had alcohol consumption once or twice weekly was significantly higher than that of those who never consumed alcohol or drinking alcohol ([334.2 ± 78.0] μmol / L], the differences were statistically significant (P <0.05). The prevalence of HUA was higher in central obesity and overdosage drinkers with an OR of 3.46 (95% CI: 1.65-7.25). No interaction of overweight or obesity and alcohol on SUA levels was found. Conclusion Overweight or obesity is an independent risk factor for HUA. Excessive alcohol consumption may lead to the increase of SUA level. Proposed males in northern China to control or reduce weight, limit alcohol consumption, in order to prevent the occurrence of HUA and gout.