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丝氨酸蛋白酶抑制剂-9(PI-9)是目前发现的惟一具有抑制颗粒酶B(GrB)功能的丝氨酸蛋白酶抑制剂,能阻断GrB所致的靶细胞凋亡,从而维持机体内环境的自稳。GrB存在于活化的细胞毒T淋巴细胞(CTL)和自然杀伤(NK)细胞中,是细胞免疫应答中最主要的效应分子。近年发现在一些肿瘤细胞中有GrB和/或PI-9的表达,并认为它们可能与肿瘤的发生、发展,免疫耐受等有关,笔者就PI-9和GrB的分子结构和功能特点以及它们在肿瘤细胞中表达和意义作一综述。
Serine protease inhibitor-9 (PI-9) is the only serine protease inhibitor found to inhibit the function of granzyme B (GrB), which can block the GrB-induced apoptosis of target cells and thus maintain the self- stable. GrB is present in activated cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells and is the most important effector molecule in the cellular immune response. In recent years, some tumor cells found in the expression of GrB and / or PI-9, and that they may be related to tumor occurrence, development, immune tolerance and so on, the author of PI-9 and GrB molecular structure and functional characteristics and their The expression and significance in tumor cells are reviewed.