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目的综合评价血管紧张素转换酶(ACE)基因插入和(或)缺失(insertion/deletion,I/D)多态性与冠心病易感性的关系。方法用关键词途径搜索了 Medline 光盘数据库(1994年1月至2005年2月)和中国医院知识仓库(CHKD)中文期刊全文库(1994年1月至2005年5月),搜集所有研究 ACE 基因多态性与冠心病易感关系的病例对照研究,应用 RevMan 4.2软件对各研究结果进行异质性检验和数据合并。结果共有16篇符合条件的文献纳入分析,累积病例1345例,累积对照1286例。同杂合子(DI)和(或)纯合子插入型(Ⅱ)基因型相比,DD(纯合子缺失型)基因型冠心病的发病风险高出156%(OR=2.56,95%CI 为2.09～3.13);ACE D 等位基因与冠心病关系的趋势性检验结果表明,随着 D 等位基因的增多发生冠心病的危险性也随之增大(χ_(Trend)~2=97.12,P<0.01)。结论 ACE 基因多态性可能与我国人群冠心病的易感性相关,DD 基因型个体冠心病的发病风险明显增高,冠心病发病风险与 D 等位基因密切相关。
Objective To evaluate the relationship between angiotensin converting enzyme (ACE) gene insertion / deletion (I / D) polymorphisms and coronary heart disease susceptibility. Methods The full-text database of Chinese Journal of Chinese Knowledge Base (CHKD) from January 1994 to February 2005 was searched through the key words and pathways (January 1994 to May 2005), and all the ACE gene A case-control study of the association between polymorphisms and susceptibility to coronary heart disease was conducted using RevMan 4.2 software to perform heterogeneity tests and data merging on each study. Results A total of 16 eligible documents were included in the analysis, with 1345 cumulative cases and 1286 cumulative controls. The DD (homozygous deletion) genotype was associated with a 156% higher risk of coronary heart disease compared with heterozygous (DI) and / or homozygous (II) genotypes (OR = 2.56, 95% CI 2.09 ~ 3.13). The trend test of ACE D allele and coronary heart disease showed that the risk of coronary heart disease increased with the increase of D allele (χ_ (Trend) 2 = 97.12, P <0.01). Conclusion The ACE gene polymorphism may be associated with the susceptibility to coronary heart disease in Chinese population. The risk of coronary heart disease is significantly higher in individuals with DD genotype. The risk of coronary heart disease is closely related to the D allele.