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[目的]观察六味地黄丸联合二甲双胍缓释片治疗阴虚热盛2型糖尿病疗效。[方法]使用随机平行对照方法,将60例住院患者按随机数字表法分为两组。对照组30例二甲双胍缓释片(中美上海施贵宝制药有限公司),0.5g/片,2次/d,口服。治疗组30例六味地黄丸,神疲乏力加人参、麦冬、五味子;阴虚火旺加知母、黄柏;尿多浑浊加益智仁、桑螵蛸等;双目干涩加枸杞、菊花。水煎服,3次/d,1剂/次,餐前半小时服用。西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、中医症候积分、FPG、2hPG、血清C肽、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效20例,有效8例,无效2例,总有效93.33率89.02%。对照组显效15例,有效10例,无效5例,总有效率83.33%。治疗组疗效优于对照组(P<0.05)。症状积分、FPG、2hPG、血清C肽改善治疗组优于对照组(P<0.05)。[结论]六味地黄丸联合二甲双胍缓释片治疗阴虚热盛2型糖尿病,疗效显著,值得推广。
[Objective] To observe the curative effect of Liuweidihuangwan combined with metformin extended release tablet on type 2 diabetes mellitus with yin deficiency and heat. [Methods] Randomized parallel method was used to divide 60 inpatients into two groups according to random number table. Control group, 30 cases of metformin sustained-release tablets (Sino-US Shanghai Squibb Pharmaceutical Co., Ltd.), 0.5g / tablet, 2 times / d, orally. The treatment group of 30 cases of Liuweidihuangwan, Shenpi fatigue plus ginseng, Ophiopogon, Schisandra; Yin Huo wwang plus Anemarrhena, Phellodendron; urine and turbid more Zhixin, mulberry 蛸; binocular dry plus wolfberry, chrysanthemum. Shuijianbi, 3 times / d, 1 / time, half an hour before meals. Western medicine treatment with the control group. Continuous treatment 7d for a course of treatment. Observed clinical symptoms, TCM symptom score, FPG, 2hPG, serum C-peptide, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. [Result] In the treatment group, 20 cases were markedly effective, 8 cases were effective and 2 cases were ineffective. The total effective rate was 93.33% and 89.02%. Control group markedly effective in 15 cases, effective in 10 cases, 5 cases, the total effective rate was 83.33%. The treatment group was better than the control group (P <0.05). Symptom score, FPG, 2hPG, serum C peptide improved treatment group than the control group (P <0.05). [Conclusion] Liuweidihuangwan combined with metformin sustained - release tablets in treatment of type 2 diabetes mellitus with yin deficiency and heat syndrome has obvious curative effect and is worth popularizing.