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对31例新生儿缺氧缺血性脑病(HIE)进行了脑电图(EEG)检查并应用放免法测定了31例HIE患儿和12例正常新生儿血浆催乳素(PRL)水平。HIE组EEG异常率为83.87％,HIE程度越重EEG异常率越高;HIE急性期PRL水平显著高于对照组(P<0.05),中、重度HIE急性期血浆PRL水平显著高于恢复期(P<0.01);惊厥组与非惊厥组急性期血浆PRL水平之间具有显著性意义(P<0.01);EEG异常的HIE患儿血浆PRL水平显著高于EEG正常组,PRL水平与EEG异常程度呈正相关关系。提示EEG可作为新生儿HIE重要的监测指标,血浆PRL水平变化不但可作为判断脑损伤严重程度的指标,亦可作为判断新生儿惊厥是否发作及EEG是否可能出现异常改变的一项参考指标。
Electroencephalography (EEG) was performed in 31 neonates with hypoxic-ischemic encephalopathy (HIE) and plasma prolactin (PRL) levels were measured in 31 HIE infants and 12 normal neonates by radioimmunoassay. The abnormal rate of EEG in HIE group was 83.87%, and the higher the HIE degree was, the higher the abnormal EEG rate was. The level of PRL in acute phase of HIE was significantly higher than that in control group (P <0.05) (P <0.01). There was a significant difference between the two groups (P <0.01). The plasma levels of PRL in children with EEG abnormalities were significantly higher than those in normal EEG groups. The levels of PRL and EEG abnormalities There was a positive correlation. It is suggested that EEG can be used as an important monitoring indicator of neonatal HIE. The change of plasma PRL level not only can be used as an index to judge the severity of brain injury, but also can be used as a reference index to determine whether neonatal seizures occur or whether EEG may be abnormally changed.