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我们按文献方法[沈阳药学院学报编辑组:药剂学专题选编,187页,1974;范文元等:医药工业(5):11.1974]自制磺胺嘧啶银时,因反应条件不同.产品质量不稳定,有时吸滤、洗涤困难。为此,我们对反应温度、时间、搅拌速度、pH 值分别作了试验,最后选用直接反应法和转化反应法进行制备.所得产品质量稳定,符合中国药典1977年版(二部,748页)要求,其操作方法亦较简便。1.直接反应法:取磺胺嘧啶(SD)粉25g混悬在300ml 水中,室温或60℃时在76-1型搅拌机高速搅拌下,缓慢加入1N AgNO_3溶液105ml,继续搅拌至搅拌困难时为止,吸滤、水洗至无 Ag~+,80℃以下干燥即得。
We according to the literature method [Journal of Shenyang Pharmaceutical University editorial group: Selected topics of Pharmacy, 187 pages, 1974; Fan Wenyuan: the pharmaceutical industry (5): 11.1974] homemade silver sulfadiazine, due to different reaction conditions, unstable product quality, Sometimes suction filter, washing difficult. To this end, we conducted a test on the reaction temperature, time, stirring speed, pH, respectively, and finally prepared by direct reaction method and conversion reaction method.The quality of the product was stable, in line with the Chinese Pharmacopoeia 1977 edition (two, p. , Its operation method is relatively simple. 1. Direct reaction: take sulfadiazine (SD) powder 25g suspended in 300ml of water at room temperature or 60 ℃ at 76-1 type mixer with high speed stirring, slowly add 1N AgNO_3 solution 105ml, stirring was continued until the mixing is difficult, Suction filtration, washed to no Ag ~ +, 80 ℃ or less dry that.