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目的探讨利用化学发光法对孕妇孕中期血清甲胎蛋白(AFP)、游离雌三醇(uE3)、β-绒毛膜促性腺激素(β-HCG)进行检测在预防出生缺陷中的价值。尽早发现可能存在的胎儿疾患,以进行早期干预。方法采用化学发光法对孕中期14-21w的孕妇血清中的AFP、uE3、β-HCG进行定量检测,输入孕妇用于筛查的信息后通过专用软件根据三者的浓度计算Down综合征(DS)、18-三体综合征和胎儿神经管缺陷(OSB)的危险性。结果 1338例孕妇筛查出Down综合征(DS)高危110例,高危阳性率为8.22%,18-三体综合征高危7例,高危率为0.52%,神经管缺陷高危(OSB)47例,高危率为3.51%,经随访59例做产前确诊检查,Down综合征阳性1例、经B超检查确诊神经管缺陷(OSB)7例。结论孕中期化学发光法检测用于筛查Down综合征、18-三体综合征、神经管缺陷,预防出生缺陷有重要意义。
Objective To explore the value of chemiluminescence in the detection of second trimester serum a-fetoprotein (AFP), free estriol (uE3) and β-chorionic gonadotropin (β-HCG) in the prevention of birth defects. Early detection of possible fetal disorders for early intervention. Methods The serum levels of AFP, uE3 and β-HCG in 14-21 w pregnant women during the second trimester were measured by chemiluminescence method. The pregnant women were screened for the information of Down syndrome (DS) ), 18-trisomy and fetal neural tube defects (OSB). Results A total of 1338 pregnant women screened out 110 high-risk patients with Down syndrome (DS), the high-risk positive rate was 8.22%, the high risk of 18-trisomy syndrome was 7, the high-risk rate was 0.52%, the high risk of neural tube defects (OSB) The high-risk rate was 3.51%. Fifty-nine patients were followed up for prenatal diagnosis and 1 was Down syndrome. Seven patients with neural tube defects (OSB) were diagnosed by B-ultrasound. Conclusion The detection of Down’s syndrome, 18-trisomy syndrome, neural tube defects and birth defects in the second trimester of pregnancy by chemiluminescence detection during pregnancy is of great significance.