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目的研究淋巴液抗失血性休克的机理。方法观察淋巴液对失血性休克大鼠心脏收缩功能和心室肌细胞动作电位的影响。结果淋巴液使失血性休克大鼠的平均动脉压、左心室收缩压和左心室内压最大上升速率具有显著回升作用 ;使心室肌细胞动作电位的 5 0 %复极化时间 (APD50 )和 90 %复极化时间显著延长 ,APD50 的延长作用可被Ca2 + 通道阻断剂阻断。结论淋巴液抗失血性休克机理可能与淋巴液促进心肌细胞Ca2 + 内流 ,增加失血性休克大鼠心脏的收缩能力有关。
Objective To study the mechanism of anti-hemorrhagic shock in lymph. Methods The effects of lymphatic fluid on cardiac contractile function and action potential of ventricular myocytes in hemorrhagic shock rats were observed. RESULTS: Lymphoid fluid significantly increased the mean arterial pressure, left ventricular systolic pressure and maximal rate of rise of left ventricular pressure in hemorrhagic shock rats. The 50% repolarization time (APD50) and 90 % Repolarization time was significantly prolonged, APD50 prolongation can be blocked by Ca2 + channel blockers. Conclusion The anti-hemorrhagic shock mechanism of lymphatic fluid may be related to the lymph infiltration of Ca2 + in cardiomyocytes and the increase of the contractile capacity of the heart in hemorrhagic shock rats.