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目的探讨老年ST段抬高型急性心肌梗死患者应用雷帕霉素洗脱支架与紫杉醇洗脱支架经皮冠状动脉介入治疗的安全性及有效性。方法 129例≥65岁ST段抬高型急性心肌梗死患者,随机分为雷帕霉素组68例和紫杉醇组61例,分别应用雷帕霉素洗脱支架与紫杉醇洗脱支架经皮冠状动脉介入治疗,分析2组患者冠状动脉靶血管特点、手术成功率及术后12个月主要不良心脏事件及术后9个月晚期管腔丢失和支架内再狭窄情况。结果手术成功率100%,2组术后9个月晚期管腔丢失和支架内再狭窄发生率差异均无统计学意义(P>0.05);2组术后12个月病死率及心肌梗死、靶血管重建、主要不良心脏事件、支架内血栓形成的发生率差异均无统计学意义(P>0.05)。结论老年ST段抬高型急性心肌梗死患者使用雷帕霉素或紫杉醇支架经皮冠状动脉介入治疗近期治疗效果和安全性均较可靠。
Objective To investigate the safety and efficacy of percutaneous coronary intervention with rapamycin-eluting stent and paclitaxel-eluting stent in elderly patients with ST-elevation acute myocardial infarction. Methods A total of 129 patients with ST-segment elevation acute myocardial infarction ≥65 years old were randomly divided into rapamycin group (n = 68) and paclitaxel group (n = 61). The patients were treated with rapamycin-eluting stent and paclitaxel- Interventional therapy was used to analyze the characteristics of target vessel of coronary artery, the success rate of surgery and major adverse cardiac events at 12 months after operation, and the loss of lumen and stent restenosis after 9 months of operation. Results The success rate of operation was 100%, there was no significant difference in the incidence of luminal loss and in-stent restenosis between the two groups (P> 0.05). The mortality and myocardial infarction, There were no significant differences in the rates of target vessel revascularization, major adverse cardiac events, and stent thrombosis (P> 0.05). Conclusion The treatment effect and safety of percutaneous coronary intervention with rapamycin or paclitaxel stent in elderly patients with ST-elevation acute myocardial infarction are more reliable.