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枸橼酸哌嗪(piperazine cotrate)是驱蛔虫有效药物之一,其药理作用是阻断蛔虫神经肌肉接头处的乙酰胆碱受体,使肌肉麻痹而达安全驱虫目的。我们自1964年以来,以本药10g大剂量分服试用于临床治疗胆道蛔虫病共100例,治愈率为100％。为进一步探讨其作用机理,而做以下实验研究. 一、材料和方法药物为国产哌嗪枸橼酸盐片剂;实验用活猪蛔虫系取自生猪屠宰时小肠内,置任氏液中备用。甲组:胆道蛔虫病患者10h内分三次服用枸橼酸哌嗪10g后,经胆总管引流胆汁80ml(胆道手术病人术
Piperazine cotrate (piperazine cotrate) is one of the effective drugs for roundworm, whose pharmacological action is to block the acetylcholine receptor at the neuromuscular junction of roundworm and to paralyze the muscle for the purpose of safe deworming. We since 1964, the drug 10g high-dose sub-trial trial for clinical treatment of biliary ascariasis in 100 cases, the cure rate was 100%. In order to further explore its mechanism of action, and to do the following experimental study.First, materials and methods of drugs for the domestic piperazine citrate tablets; experimental live pig roundworm was taken from the pig intestine when slaughtered, . Group A: patients with biliary ascariasis in 10h within three times taking citrate piperazine 10g, the common bile drainage through the common bile 80ml (biliary surgery patients