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为观察高原对大鼠血浆与组织6一Keto一PGF_(1α)和TXB_2含量的影响及丹参的保护作用。采用3H一TXB_2及3H-6一Keto一PGF_(1α)药盒及方法。结果:平原大鼠进入海拔4475m高原后,其心、肝、脾脏组织及血浆中血栓素B_2(TXB_2)含量显著升高(P<0.05);心脏和血浆中6一酮一前列腺素F_(1α)(6一Keto一PGF_(1α))含量则显著降低(P<0.01);各项T/K比值均显著增大(P<0.01),丹参合剂能有效地预防高原低氧环境对大鼠的上述影响(P<0.05或P<0.01)。提示该药用于防治而原疾病值得深入研究。
To observe the plateau on the plasma and tissue 6-Keto-PGF_ (1α) and TXB_2 levels and the protective effect of Salvia miltiorrhiza. 3H-TXB_2 and 3H-6-Keto-PGF_ (1α) kit and method were used. Results: The content of TXB_2 in the heart, liver, spleen and plasma was significantly increased in plain rats after entering the altitude of 4475m (P <0.05). The levels of 6-keto-PGF_ (1α) (6-Keto-PGF_ (1α)) was significantly decreased (P <0.01), and the ratio of T / K increased significantly (P <0.01). Salvia miltiorrhiza mixture could effectively prevent plateau The above effects of hypoxic environment on rats (P <0.05 or P <0.01). Suggesting that the drug used for prevention and treatment of the original disease worth further study.