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目的检测CXCL12、CXCR4在非小细胞肺癌(NSCLC)组织及癌旁正常肺组织中的表达情况,分析其阳性表达的意义及其阳性表达与NSCLC相关参数的联系。方法采用免疫组织化学染色方法对临床确诊的NSCLC癌组织、离其最短径5 cm以上正常肺组织标本62例进行检测。结果 NSCLC细胞CXCL12、CXCR4与NSCLC癌旁正常肺组织阳性表达率差异有统计学意义(P<0.05);与NSCLC的TNM分期、纵隔淋巴结转移等差异有统计学意义(P<0.05)。结论 CXCL12、CXCR4在NSCLC组织中表达能够促进NSCLC癌组织的浸润、发展及转移,并且与纵隔淋巴结转移有关;其表达是专一性的,具有靶向性。
Objective To detect the expression of CXCL12 and CXCR4 in non-small cell lung cancer (NSCLC) tissues and adjacent normal lung tissues, and to analyze the relationship between the positive expression of CXCL12 and CXCR4 and the related parameters of NSCLC. Methods Immunohistochemical staining was used to detect 62 cases of NSCLC cancerous tissue which was diagnosed from the normal lung tissue with the shortest diameter of 5 cm or more. Results The positive rates of CXCL12, CXCR4 and normal lung tissue adjacent to NSCLC were statistically different (P <0.05). The differences were statistically significant (P <0.05) between TNM stage and mediastinal lymph node metastasis of NSCLC. Conclusion The expression of CXCL12 and CXCR4 in NSCLC tissues can promote the infiltration, development and metastasis of NSCLC, and is related to the mediastinal lymph node metastasis. The expression of CXCL12 and CXCR4 is specific and targeted.