Background and Study Aims: Endoscopic ultrasonography (EUS) is the most accurate method of assessing the locoregional extent of cancer of the esophagus and esophagogastric junction. The aim of this study was to evaluate the influence of tumor-related factors such as length and location on the accuracy of EUS in staging these tumors. Patients and Methods: Between January 1997 and September 2002, 280 consecutive patients underwent preoperative EUS for staging cancer of the esophagus and esophagogastric junction. The influence of histopathology, the pres ence of Barrett’s dysplasia or stenosis, and the location and length of the pri mary tumor on the accuracy of EUS for T, N, and Mstaging were studied. Results: The overall accuracy rates of EUS for assessing the T, N, and Mstages were 73 %, 80%, and 78%, respectively. The influence of the tumor’s histopathology and the presence of Barrett’s dysplasia or stenosis was minimal. The accuracy of EUS was greater in tumors 5 cmor less in size than in tumors larger than 5 cm (82%vs. 52%forthe Tstage, P < 0.05; 88%vs. 59%for the N stage, P < 0.05; an d 92%vs. 56%for the M stage, P < 0.001). The low accuracy of Tstaging in larger tumors may be due to the exclusion of patients with local unresectability or distant metastases. EUS was also significantly better in esophageal tumors, part icularly for identifying celiac trunk metastases (93%vs. 63%; P < 0.001). Conc lusions: The accuracy of EUS for staging esophageal cancer is lower in tumors la rger than 5 cm and in esophagogastric junction tumors than in tumors 5 cm in siz eorless and in esophageal tumors. These findings should be considered when treat ment decisions are being taken. Background and Study Aims: Endoscopic ultrasonography (EUS) is the most accurate method of assessing the locoregional extent of cancer of the esophagus and esophagogastric junction. The aim of this study was to evaluate the influence of tumor-related factors such as length and location on The accuracy of EUS in staging these tumors. Patients and Methods: Between January 1997 and September 2002, 280 consecutive patients underwent preoperative EUS for staging cancer of the esophagus and esophagogastric junction. The influence of histopathology, the pres ence of Barrett’s dysplasia or stenosis, Results: The overall accuracy rates of EUS for assessing the T, N, and Mstages were 73%, 80%, and 78%, respectively. The influence of the tumor’s histopathology and the presence of Barrett’s dysplasia or stenosis was minimal. The accuracy of EUS was greater in tumors 5 cm less in size th an in tumor larger than 5 cm (82% vs. 52% forthe Tstage, P <0.05; 88% vs. 59% for the N stage, P <0.05; <0.001). The low accuracy of Tstaging in larger tumors may be due to the exclusion of patients with local unresectability or distant metastases. EUS was also significantly better in esophageal tumors, part icularly identifying celiac trunk metastases (93% vs. 63% ; P <0.001) Concusions: The accuracy of EUS for staging esophageal cancer is lower in tumors larger than 5 cm and in esophagogastric junction tumors than in tumors 5 cm in siz eorless and in esophageal tumors. These findings should be considered when treat ment decisions are being taken.