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目的:探讨KLOTHO基因启动子区G-395A多态性与中国苏皖地区汉族人群急性冠脉综合征(acute coronary syndrome,ACS)的关系。方法:采用聚合酶链反应和基因芯片方法对326例ACS(ACS组)[分为亚组急性心肌梗死(acute myocardial infarction,AMI)组和不稳定性心绞痛(unstable angina pectoris,UAP)组]和219例经检查排除冠心病的对照组进行KLOTHO基因G-395A多态性分析。结果:与对照组相比,ACS组、AMI组和UAP组(包括不同年龄和不同性别的亚组)的GG、GA、AA基因型和A等位基因频率均无明显差异(P>0.05)。结论:KLOTHO基因G-395A多态性与中国苏皖地区汉族人群ACS的发病无显著相关性。
Objective: To investigate the relationship between G-395A polymorphism in KLOTHO gene promoter region and acute coronary syndrome (ACS) in Han population in Jiangsu and Anhui Provinces. Methods: A total of 326 ACS patients were divided into subgroups with acute myocardial infarction (AMI) and unstable angina pectoris (UAP) by polymerase chain reaction and gene chip. 219 cases of patients with coronary heart disease were excluded from the control group for KLOTHO gene G-395A polymorphism. Results: There was no significant difference in the frequencies of GG, GA, AA genotypes and A alleles between ACS group, AMI group and UAP group (including subgroups of different ages and genders) compared with the control group (P> 0.05) . Conclusion: There is no significant correlation between the KLOTHO gene G-395A polymorphism and the incidence of ACS in Han population of Jiangsu and Anhui Provinces.