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目的 :探讨血清甲胎蛋白 (AFP)、唾液酸 (SA )、α- L -岩藻糖苷酶 (AFU )及转化生长因子β1 (TGF-β1 )各项标志物在肝病患者中对 PHC的诊断价值及联合检测的意义。方法 :对 2 2 6例肝病患者血清中各项标志物的水平进行检测并对阳性率进行计算。结果 :各种标志物诊断 PHC的敏感性为 AFU(93.2 % ) >TGF- β1 (80 .0 % ) >AFP(72 .9% ) >SA(6 7.8% ) ,特异性为 SA(94.6 % ) >AFP(83.8% ) >TGF- β1 (82 .0 % ) >AFU(79.0 % ) ,联合 4项检测可将阳性率提高到 96 .6 %。结论 :多项肿瘤标志物联合检测对 PHC尤其是 AFP阴性 PHC的诊断具有重要价值
Objective: To investigate the diagnostic value of serum AFP, SA, AFU and TGF-β1 in patients with liver disease Value and significance of joint testing. Methods: The levels of serum markers in 226 cases of liver disease were detected and the positive rate was calculated. Results: The sensitivities of various markers for the diagnosis of PHC were as follows: AFU (93.2%)> TGF- β1 (80.0%)> AFP (72.9%)> SA )> AFP (83.8%)> TGF-β1 (82.0%)> AFU (79.0%). The combination of 4 tests increased the positive rate to 96.6%. Conclusions: The combined detection of multiple tumor markers is of great value in the diagnosis of PHC, especially AFP-negative PHC