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27例抗恶性淋巴瘤患者,中位年龄27岁,其中非何杰金氏淋巴瘤24例,何杰金氏淋巴瘤3例。双侧骨髓活检组织学正常,缓解或复发时取骨髓冰冻保存。在常规联合化疗失败后用环磷酰胺、全身放疗和自身骨髓移植治疗,以后不再化疗。用环磷酰胺60mg/kg体重,在移植前第5、4天静脉输入。移植前用钻或X线全身照射,总量为1,000—1600拉德。输入骨髓细胞的中位剂量为1.9×10~8有核细胞/kg体重。骨髓中位保存时间为19天。血液成份经2,500拉德照射后在需要时输入,以维持血红蛋白>9g％,血小板>10,000/μl。治疗后,15例获完全缓解,其中5例在移植后未再治疗,已连续缓解19—71个月。外周血中性粒细胞恢复到500/μl以上和血小板恢复到10,000/μl以上的中位
27 patients with anti-malignant lymphoma, the median age 27 years, of which 24 cases of non-Hodgkin’s lymphoma, Hodgkin’s lymphoma in 3 cases. Bilateral bone marrow biopsy histology normal, bone marrow recovery or cryogenic preservation. After the failure of conventional combination chemotherapy with cyclophosphamide, systemic radiotherapy and bone marrow transplantation, no chemotherapy after. Cyclophosphamide 60mg / kg body weight, 5,4 days before transplantation, intravenous infusion. A total of 1000-1600 rads were irradiated with a full-bore or X-ray before transplantation. The median dose of bone marrow cells was 1.9 × 10 ~ 8 nucleated cells / kg body weight. Median bone marrow preservation time was 19 days. Blood components were irradiated at 2,500 rads, when needed, to maintain hemoglobin> 9 g% and platelets> 10,000 / μl. After treatment, 15 patients were completely relieved, of which 5 were not re-treated after transplantation, has been continuously relieved 19-71 months. Peripheral blood neutrophils returned to more than 500 / μl and platelets recovered to more than 10,000 / μl