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目的:探讨呼吸窘迫综合征(NRDS)及感染性肺炎患儿甲状腺激素、IL-6、TNF-α的变化及其相关性。方法:将45例NRDS患儿和59例新生儿感染性肺炎患儿作为NRDS组和感染性肺炎组,所有患儿均于入院时和撤离呼吸机后检测血清T3、T4、FT3、FT4、TSH、r T3、TNF-α、IL-6水平变化情况,分析血清甲状腺激素与TNF-α、IL-6的相关性。结果:NRDS组患儿治疗后血清T3、T4、FT3、FT4水平均显著升高,IL-6水平显著下降(P<0.05);感染性肺炎组患儿治疗后血清T3水平显著升高,TSH、TNF-α、IL-6水平显著下降(P<0.05);NRDS组患儿血清IL-6与T3、FT3、T4、FT4均呈负相关(r=-0.793,P=0.000;r=-0.529,P=0.003;r=-0.396,P=0.030;r=-0.549,P=0.002);感染性肺炎组患儿血清T3与TNF-α、IL-6均呈现负相关(r=-0.887,P=0.000;r=-0.745,P=0.000)。结论:NRDS患儿伴有血清T3、T4、FT3、FT4下降和IL-6升高,血清IL-6与T3、FT3、T4、FT4均呈负相关;感染性肺炎患儿伴有血清T3下降和TSH、TNF-α、IL-6水平升高,血清T3与TNF-α、IL-6均呈现负相关。
Objective: To investigate the changes of thyroid hormones, IL-6 and TNF-α in children with respiratory distress syndrome (NRDS) and infectious pneumonia. Methods: Forty-five children with NRDS and 59 neonates with infectious pneumonia were selected as NRDS group and infectious pneumonia group. All patients were examined for serum T3, T4, FT3, FT4, TSH at admission and after ventilator withdrawal , R T3, TNF-α and IL-6 levels in serum were measured. The correlation between serum thyroid hormones and TNF-α and IL-6 was analyzed. Results: Serum levels of T3, T4, FT3 and FT4 were significantly increased and IL-6 levels were significantly decreased in children with NRDS (P <0.05). Serum T3 was significantly increased in children with infectious pneumonia after treatment, and TSH , IL-6, TNF-α, IL-6 in NRDS group were significantly decreased (P <0.05) 0.529, P = 0.003; r = -0.396, P = 0.030; r = -0.549, P = 0.002). There was a negative correlation between serum T3 and TNF-α and IL-6 in children with infectious pneumonia (r = -0.887 , P = 0.000; r = -0.745, P = 0.000). CONCLUSIONS: Serum levels of T3, T4, FT3, FT4 are decreased and IL-6 is elevated in children with NRDS. Serum IL-6 is negatively correlated with T3, FT3, T4 and FT4. Serum T3 is decreased in children with infectious pneumonia And TSH, TNF-α, IL-6 levels, serum T3 and TNF-α, IL-6 showed a negative correlation.