多发性硬化(MS)是一种慢性炎症神经变性疾病,由于缺乏对其病理机制的了解,阻碍了治疗手段的改进。Steinman等在Nature上报道,中枢神经系统多发性硬化损伤的大规模蛋白质组学分析有助于找到该病的新药靶标。多发性硬化损伤依据疾病的活动水平呈现不同的特点。研究者应用激光捕获 Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder that hinders improvements in treatment due to a lack of understanding of its pathological mechanisms. Steinman et al. Reported in Nature that large-scale proteomic analysis of multiple sclerosis damage in the central nervous system can help identify new drug targets for the disease. Multiple sclerosis lesions show different characteristics depending on the level of activity of the disease. Researchers apply laser capture