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目的研究应用盐酸戊乙奎醚对慢性阻塞性肺病(COPD)患者心率变异性(HRV)和呼吸道分泌物的影响。方法选择COPD患者48例气管内插管应用呼吸机后静注盐酸戊乙奎醚1 mg。观察注药前、注药后2、4、6 h的心率(HR)、心率变异总功率(TP)、低频(LF)、高频(HF)、低频/高频(LF/HF)及呼吸道分泌物的变化。结果所有患者注药后2、4、6 h HR、及HRV各指标与注药前比较差异无显著性(P>0.05);呼吸道分泌物明显减少(P<0.05)。结论盐酸戊乙奎醚不影响COPD患者的心率变异性,并且能减少呼吸道分泌物,有利于COPD患者的预后。
Objective To investigate the effect of penehyclidine hydrochloride on heart rate variability (HRV) and respiratory secretions in patients with chronic obstructive pulmonary disease (COPD). Methods Forty-eight patients with COPD received intravenous penehyclidine 1 mg intravenously after ventilator. The heart rate (HR), total heart rate variability (TP), low frequency (LF), high frequency (HF), low frequency / high frequency (LF / HF) and respiratory tract Changes in secretions. Results The HR, HRV and HRV indexes of all patients at 2, 4 and 6 h after injection were not significantly different from those before drug injection (P> 0.05). Respiratory secretions were significantly decreased (P <0.05). Conclusion Penehyclidine hydrochloride does not affect heart rate variability in patients with COPD, and can reduce respiratory secretions, is conducive to the prognosis of patients with COPD.