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目的：建立合适的慢性实验性糖尿病大鼠大脑中动脉梗死模型。方法：３０只雄性ＳＤ大鼠分组注入不同剂量ＳＴＺ，诱导产生实验性糖尿病，比较不同剂量、不同病程时糖尿病大鼠的症状、体征及存活率，再制作糖尿病大鼠 ＭＣＡＯ模型，观察该模型的死亡率和并发症，筛选对照组。结果：ＳＴＺ ５５ｍｇ·ｋｇ－１诱导４０～４７ｄ糖尿病大鼠存活率高（Ｐ＜０．０５），慢性并发症充分，能较好地耐受 ＭＣＡＯ手术，麻醉剂量宜减少１０％～２０％。１４０～１８０ｇ正常ＳＤ大鼠是糖尿病４０～４７ｄ大鼠较好的对照组。结论：ＳＴＺ ５５ｍｇ．ｋｇ－１诱导４０～４７ｄ糖尿病大鼠大脑中动脉梗死模型是一良好的动物模型，可以为进一步研究糖尿病和脑缺血的关系提供帮助。
Objective: To establish a suitable model of middle cerebral artery occlusion in chronic experimental diabetic rats. Methods: Thirty male Sprague-Dawley rats were injected with different doses of STZ to induce experimental diabetes mellitus. The symptoms, signs and survival rates of diabetic rats at different doses and different durations were compared. Then MCAO model of diabetic rats was made. Mortality and complications, screening control group. Results: STZ 55mg · kg-1 induced 40 ~ 47d diabetic rats with high survival rate (P <0.05). Chronic complications were adequate and MCAO surgery was well tolerated. The dosage of STZ should be reduced by 10% -20%. 140 ~ 180g normal SD rats is a good control group of 40 ~ 47d diabetic rats. Conclusion: STZ 55mg. kg-1 is a good animal model for inducing middle cerebral artery occlusion (MCAO) in 40-47 d diabetic rats, which may help to further study the relationship between diabetes and cerebral ischemia.