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目的探讨血清瘦素(Lp)和可溶性瘦素受体(sLR)与不同临床分型的红斑狼疮(LE)及系统性红斑狼疮(SLE)病情活动程度的关系。方法于2004年6月至2005年12月对中国医科大学附属第二医院和中国医科大学附属第一医院的39例LE患者,同年龄、性别、体重指数(BMI)均相匹配的31名健康人对照,采用放射免疫法和酶联免疫吸附实验(ELISA)检测血清Lp和sLR水平。结果(1)与正常对照相比较,LE患者血清Lp水平增高和sLR水平下降,差异有统计学意义(P<0.01),活动期SLE患者血清Lp水平增高和sLR水平下降尤为显著;但非活动期SLE、亚急性皮肤型红斑狼疮(SCLE)和盘状红斑狼疮(DLE)患者血清Lp和sLR水平差异无统计学意义(P>0.05)。(2)Lp与BMI呈正相关,与sLR呈负相关;SLE患者的病情活动程度与血清Lp水平呈正相关,与sLR水平呈负相关(P<0.01)。结论Lp和sLR水平异常可能与LE的发病密切相关。
Objective To investigate the relationship between serum leptin (Lp) and soluble leptin receptor (sLR) and the activity of different clinical types of lupus erythematosus (LE) and systemic lupus erythematosus (SLE). Methods From June 2004 to December 2005, 39 healthy subjects with LE in the Second Affiliated Hospital of China Medical University and the First Affiliated Hospital of China Medical University were enrolled. Twenty-one healthy subjects with the same age, gender and body mass index (BMI) Human control, serum Lp and sLR levels by radioimmunoassay and enzyme-linked immunosorbent assay (ELISA). Results (1) The levels of serum Lp and sLR in LE patients were significantly lower than those in normal controls (P <0.01). The levels of serum Lp and sLR in patients with active SLE were significantly lower than those in controls Serum Lp and sLR levels in patients with SLE, subacute cutaneous lupus erythematosus (SCLE) and discoid lupus erythematosus (DLE) were not significantly different (P> 0.05). (2) Lp was positively correlated with BMI and negatively correlated with sLR. The severity of SLE patients was positively correlated with serum Lp level and negatively correlated with sLR level (P <0.01). Conclusions Abnormal Lp and sLR levels may be closely related to the pathogenesis of LE.